Journal article
PET/CT Lung Ventilation and Perfusion Scanning using Galligas and Gallium-68-MAA
PY Le Roux, RJ Hicks, S Siva, MS Hofman
Seminars in Nuclear Medicine | W B SAUNDERS CO-ELSEVIER INC | Published : 2019
Abstract
Ventilation/Perfusion (V/Q) positron emission tomography computed tomography (PET/CT) is now possible by substituting Technetium-99m (99mTc) with Gallium-68 (68Ga), using the same carrier molecules as conventional V/Q imaging. Ventilation imaging can be performed with 68Ga-carbon nanoparticles using the same synthesis device as Technegas. Perfusion imaging can be performed with 68Ga-macroaggregated albumin. Similar physiological processes can therefore be evaluated by either V/Q SPECT/CT or PET/CT. However, V/Q PET/CT is inherently a superior technology for image acquisition, with higher sensitivity, higher spatial and temporal resolution, and superior quantitative capability, allowing more ..
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Grants
Awarded by Cancer Australia
Funding Acknowledgements
We would like to acknowledge the doctors, radiopharmacists, nuclear medicine technologists, nurses, and medical physicists at the Peter MacCallum Cancer Team who have enabled this research to occur. In particular, we would like to acknowledge our radiopharmacist, Mr Peter Eu, for on demand production and Dr Jason Callahan for his work optimizing acquisition parameters. We would also like to acknowledge Dr Jean-Mathieu Beauregard who wrote the initial protocol for the feasibility study comparing V/Q SPECT and PET in 2010. Much of this work has been possible by our clinical collaborators including radiation oncology/medical physics (Dr Nicholas Hardcastle), respiratory medicine (A/Prof Daniel Steinfort, A/Prof Lou Irving) and cardiothoracic surgery (Mr Stephen Barnett). Prof Hofman and A/Prof Siva are each supported by a Clinical Fellowship from the Peter MacCallum Foundation. Part of this research has been supported by Cancer Australia Priority-driven Collaborative Cancer Research Scheme Grant 2013, APP1060919. Prof Hicks is supported by a National Health and Medical Research Practitioner Fellowship, APP1108050.